http://www.fluoroprobe.com/archives/tag/%e7%82%b9%e6%a0%b7 WebAbstract We have developed a highly active and well-tolerated camptothecin (CPT) drug-linker designed for antibody-mediated drug delivery in which the lead molecule consists of a 7-aminomethyl-10,11-methylenedioxy CPT (CPT1) derivative payload attached to a novel hydrophilic protease-cleavable valine-lysine-glycine tripeptide linker.
Camptothecin - an overview ScienceDirect Topics
WebSynonym(s): Camptothecin, 10-Hydroxy-, Camptotheca acuminata. Empirical Formula (Hill Notation): C 20 H 16 N 2 O 5. CAS No.: 64439-81-2. Molecular Weight: 364.35. Compare Product No. Description SDS … WebPrimary Care CME in beautiful family-friendly resort destinations. MCE Conferences provides half-day format continuing medical education programs that are always 100% free of commercial influence. Our CME … harley touring ignition switch relocation
Camptothecin - Wikipedia
WebFeb 24, 2024 · In line with GDF15's anorectic effect, CPT suppresses food intake, thereby reducing body weight, blood glucose, and hepatic fat content in obese mice. Conversely, CPT loses these beneficial effects when Gdf15 is inhibited by a neutralizing antibody or AAV8-mediated liver-specific knockdown. WebTopotecan (Hycamtin), a semisynthetic water-soluble derivative of camptothecin, is a potent inhibitor of DNA topoisomerase I in vitro and has demonstrated encouraging … WebCamptothecin (CPT, 1) is a plant alkaloid from the Camptotheca acuminata tree. 83 In in vitro assay, camptothecin exhibited excellent topoisomerase I inhibitory activity but poor water solubility (2.5×10 −3 mg ml −1) and unpredictable toxicity. In an attempt to improve both the toxicological profile and the water solubility, a variety of ... channel thumbnail maker