Solubility of theophylline in water
WebFeb 27, 2024 · Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE; Ki = 100 μM). It is also a non-selective antagonist of adenosine A receptors (Ki = 14 μM for A1 and A2). Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117 μM; EC80 = 208 μM). WebTheophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is …
Solubility of theophylline in water
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WebThe solubility of theophylline – oxalic acid co-crystal and theophylline – glutaric acid co-crystal was determined in 4:1 chlroform – methanol and in pure chloroform respectively. At equilibrium with the solid theophylline – oxalic acid co-crystal, the theophylline concentration is only 60 % of the corresponding value for the WebApr 14, 2024 · Purpose Nitrofurantoin is an effective antibacterial drug for the treatment of lower urinary tract infection. However, the anhydrate form can easily transform to the less soluble hydrate form (monohydrate) during dissolution, resulting in a reduction of dissolution rate and oral bioavailability. Therefore, inhibition of phase transformation is …
WebSolubility: Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in … WebAug 1, 1994 · The results were treated on the basis of the extended Hildebrand solubility approach considering interaction terms. An equation has been obtained for predicting the …
WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was … WebTheophylline is a cyclic phosphodiesterase inhibitor. It antagonizes Adenosine A Receptors and weakly inhibits alkaline phosphodiesterases and 5′-nucleotidase. ... Soluble in water (8.3 g/l) at 20° C, 0.1 M NaOH, 0.1 M HCl, ethanol (moderately), DMSO, alkali hydroxides, ammonia, dilute hyrochloric acid, nitric acid, ...
WebIn the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Compared to the solubility in distilled …
WebCaffeine, theobromine, and theophylline are all more fat soluble than they are water soluble. 5 mo. ago. Thank you! Does the extra methyl group on caffeine (as opposed to theophylline, theobromine and paraxanthine) not make a difference? Patrick26. The presence or absence of that methyl group does affect the solubilities, but they are still ... solventless laminationWebAug 3, 2010 · The solubility of theophylline in water was modeled including hydrate formation (1:1) as well as polymorphic transitions of theophylline between the anhydrate … small brown bird long beak short tailWebJun 16, 2024 · From the observation, the Theophylline is more soluble in sodium salicylate hydrotrope than other three hydrotropes. Since it is a water soluble molecular structure … small brown birds in ohioWebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. It was found that the solubility of theobromine, theophylline, … small brown birds identification uksmall brown birds in ctWebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ... solventless rosin cartridge strainWebThe observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based on the Extended Simultaneous Chemical Reaction and … solventless aldol reaction